Drosophila melanogaster

A complete fly brain.

166,700 neurons. 25.6 million connections.
One fruit fly, and a registry of experiments to put them through.

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Our fly, named Specimen 237: a micro-CT-derived body with 69 articulated segments, and the MaleCNS v1.0 nervous system. Drag to rotate both.

Built from real anatomy.

Body

The fly’s body is the NeuroMechFly model: 69 segments derived from micro-CT scans of a female Drosophila melanogaster, articulated joint by joint.

Brain

The nervous system is MaleCNS v1.0 from FlyEM at HHMI Janelia: the complete male central nervous system, run as 166,700 leaky integrate-and-fire units with fixed weights.

Eyes

Each experiment renders what the fly sees from its own head. Display settings change what you see, never what it sees.

Beyond the eyes. Dedicated experiments deliver smell, taste, touch, hearing, temperature, humidity and limb-position input to the fly’s matching sensory neurons.

The body and the nervous system come from different specimens and are not anatomically registered. Read the specimen file

Every scene is rendered.Every spike is recorded.

Each scene is built and rendered in 3D. What the fly sees is rendered from its own head and delivered, as retinal input, to a spiking model of the complete male fruit fly central nervous system. The spikes that follow are recorded, not drawn.

Experiment No. 0020 · Master Mason

Raised to the sublime degree.

A 52-stage lodge ceremony condensed from Duncan’s Ritual of Freemasonry (1866). Twenty-seven flies hold the offices and walk the circuits. Our fly is the candidate.

Run this experimentExperiment notes

Runs in your browser, with the compound-eye inspector and a simulated neural panel.

The lodge, with the brethren gathered for the raising

7 experiments run in your browser.

Pick a camera, switch to wireframe, look through the compound eye and open the neural panel.

See all browser experiments

166,700

Neurons in the model

MaleCNS v1.0 · FlyEM / Janelia

25,582,938

Directed connections

Fixed weights

69

Articulated body segments

NeuroMechFly · micro-CT

68

Experiments in the registry

And counting

From the registry.

All experiments

The Workstation

Run it yourself.

Research Associates get the workstation’s complete source code: every experiment, the full connectome model, the neuron anatomy viewer and the instrument panels. Run it on your own computer once the prerequisites are installed.

The workstation running the double-slit experiment, with neural activity panels

Included with Research Associate, $10 a month.

Mac · Windows · Linux

Research Associates also suggest and vote on the next experiments.

Become a Research AssociateSetup guide

Commission an Experiment.

Name what the fly should do. It is built, run on the full workstation and delivered as a 1–4 minute recording. Your name stays on its permanent page in the registry.

Follow the fly.

Recordings are published on these channels.